Mavis`s Bio (April 2019)
My journey with Mesothelioma began as so many Patients find with the day I couldn’t breathe.
I was rushed to A&E and they had found a bed for me,where they drained 7ltrs of fluid. So my lung had collapsed and my diaphragm had bent.
They found Mesothelioma cells when testing the fluid. And I was given a 3 months Prodgnosis.
After going to Guys hospital, where I had a pleurodesis, I came home with a drain.
The Bi-op that had been carried out at the same time confirmed the Diagnosis.
4 Years of Chemotherapy then followed with shrinkage then regrowth 4 times within those years. I became too toxic and I was told there was no more treatment.
I had already made it known I was interested in any trial and Immunotherapy was just being investigated.
MSD had this trial at the Royal Marsden and I was referred there on my request as Dean Fennel thought it would suit me. Prof De Bono agreed and I was one of 3 patients to start MK3475-28.
I had complete response. It was only because I had Sepsis right at the end of the 2 year trial that I didn’t get that result included in the final figures in time so Im under the heading of ongoing. That was disappointing.
I had 2 years freedom but then last March new growth showed. The old Meso was still in remission though. The new growth was bi-oped and it was found it was full of PDL1 where as I only had 1% before.
I became the first patients in the world to re-challenge the drug. Within 4 infusions it shrunk 14% and then stopped.
It is growing again very slowly, not enough to bi-op yet. The Royal Marsden have matched my DNA to a drug that they can use to boost Pembro and maybe kick it in to work again. That is in the future.
I keep busy raising awareness of Asbestos and the dangers to Health and Safety today as the tradesmen work where the asbestos is hiding and the awareness of how important it is to use the right mask and to have Face/Fit training.
Also the Awareness of Mesothelioma and how we need to talk to each other. I run the Social Media as well as My Charity The Mavis Nye Foundation
Mavis and Ray Nye’s story – a case study of mesothelioma caused by exposure to dust at work
I was rushed to A&E and they had found a bed for me,where they drained 7ltrs of fluid. So my lung had collapsed and my diaphragm had bent.
They found Mesothelioma cells when testing the fluid. And I was given a 3 months Prodgnosis.
After going to Guys hospital, where I had a pleurodesis, I came home with a drain.
The Bi-op that had been carried out at the same time confirmed the Diagnosis.
4 Years of Chemotherapy then followed with shrinkage then regrowth 4 times within those years. I became too toxic and I was told there was no more treatment.
I had already made it known I was interested in any trial and Immunotherapy was just being investigated.
MSD had this trial at the Royal Marsden and I was referred there on my request as Dean Fennel thought it would suit me. Prof De Bono agreed and I was one of 3 patients to start MK3475-28.
I had complete response. It was only because I had Sepsis right at the end of the 2 year trial that I didn’t get that result included in the final figures in time so Im under the heading of ongoing. That was disappointing.
I had 2 years freedom but then last March new growth showed. The old Meso was still in remission though. The new growth was bi-oped and it was found it was full of PDL1 where as I only had 1% before.
I became the first patients in the world to re-challenge the drug. Within 4 infusions it shrunk 14% and then stopped.
It is growing again very slowly, not enough to bi-op yet. The Royal Marsden have matched my DNA to a drug that they can use to boost Pembro and maybe kick it in to work again. That is in the future.
I keep busy raising awareness of Asbestos and the dangers to Health and Safety today as the tradesmen work where the asbestos is hiding and the awareness of how important it is to use the right mask and to have Face/Fit training.
Also the Awareness of Mesothelioma and how we need to talk to each other. I run the Social Media as well as My Charity The Mavis Nye Foundation
Mavis and Ray Nye’s story – a case study of mesothelioma caused by exposure to dust at work